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There are several matches for 'Ser protein kinase'.
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2283 matches
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organism
protein
1)
Homo sapiens
FAM20C - Extracellular serine/threonine
protein
kinase
FAM20C; Golgi serine/threonine
protein
kinase
that phosphorylates secretory pathway
proteins
within
Ser
-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main
protein
kinase
for extracellular
proteins
, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates
proteins
within the
Ser
-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of
proteins
involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. I [...]
[a.k.a. Golgi casein kinase, ENST00000512382, GEF-CK]
2)
Homo sapiens
HIPK4 - Homeodomain-interacting
protein
kinase
4;
Protein
kinase
that phosphorylates human TP53 at
Ser
-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential); Belongs to the
protein
kinase
superfamily. CMGC Ser/Thr
protein
kinase
family. HIPK subfamily.
[a.k.a. hsa:147746, ENST00000452139, ENSP00000397736]
3)
Homo sapiens
MAPK6 - Mitogen-activated
protein
kinase
6; Atypical MAPK
protein
. Phosphorylates microtubule-associated
protein
2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at
Ser
-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity); Belongs to the
protein
kinase
superfamily. CMGC Ser/Thr
protein
kinase
family. MAP
kinase
s [...]
[a.k.a. R-HSA-162582, 2I6L, Mitogen-activated protein kinase 4/6]
4)
Homo sapiens
MAPK4 - Mitogen-activated
protein
kinase
4; Atypical MAPK
protein
. Phosphorylates microtubule-associated
protein
2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at
Ser
-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity); Belongs to the
protein
kinase
superfamily. CMGC Ser/Thr
protein
kinase
family. MAP
kinase
s [...]
[a.k.a. ENST00000540640, Erk4, UPI00024D146E]
5)
Homo sapiens
TSSK4 - Testis-specific serine/threonine-protein
kinase
4; Serine/threonine
kinase
which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on '
Ser
-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on '
Ser
-116' in vitro (By similarity). Phosphorylates ODF2 on '
Ser
-95' (By similarity). Belongs to the
protein
kinase
superfamily. CAMK Ser/Thr
protein
kinase
family.
[a.k.a. ENSP00000287913, C14orf20, Q6SA08]
6)
Homo sapiens
NUAK2 - NUAK family SNF1-like
kinase
2; Stress-activated
kinase
involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate '
Ser
-464' of LATS1. Belongs to the
protein
kinase
superfamily. CAMK Ser/Thr
protein
kinase
family. SNF1 subfamily.
[a.k.a. BAC11234.1, SNARK, NP_112214]
7)
Homo sapiens
SIK2 - Serine/threonine-protein
kinase
SIK2; Phosphorylates '
Ser
-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators; Belongs to the
protein
kinase
superfamily. CAMK Ser/Thr
protein
kinase
family. SNF1 subfamily.
[a.k.a. Q6AZE2, ENSG00000170145, URS0000CF29C3]
8)
Homo sapiens
TP53RK - EKC/KEOPS complex subunit TP53RK; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical
protein
kinase
that phosphorylates '
Ser
-15' of p53/TP53
protein
and may t [...]
[a.k.a. BC009727, BC066309, prpk]
9)
Homo sapiens
ATM - Serine-
protein
kinase
ATM; Serine/threonine
protein
kinase
which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates '
Ser
-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]
[a.k.a. XM_017017792, ATM-212, M0QXY8]
10)
Homo sapiens
TESK2 - Dual specificity testis-specific
protein
kinase
2; Dual specificity
protein
kinase
activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at '
Ser
- 3'. May play an important role in spermatogenesis.
[a.k.a. ENSP00000312781, 2.7.12.1, NP_009101]
11)
Homo sapiens
ADCK2 - Uncharacterized aarF domain-containing
protein
kinase
2; The function of this
protein
is not yet clear. It is not known if it has
protein
kinase
activity and what type of substrate it would phosphorylate (
Ser
, Thr or Tyr).
[a.k.a. Q7Z695, XM_011516675, AAP60021.1]
12)
Homo sapiens
ADCK5 - Uncharacterized aarF domain-containing
protein
kinase
5; The function of this
protein
is not yet clear. It is not known if it has
protein
kinase
activity and what type of substrate it would phosphorylate (
Ser
, Thr or Tyr).
[a.k.a. XP_011515209, AAH64345.1, ADCK5_HUMAN]
13)
Homo sapiens
PHLPP2 - PH domain leucine-rich repeat-containing
protein
phosphatase 2;
Protein
phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr
protein
kinase
family; specifically acts on '
Ser
-473' of AKT1, '
Ser
-660' of PRKCB isoform beta-II and '
Ser
-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of '
Ser
-473' of Akt triggers apopto [...]
[a.k.a. 3.1.3.16, ENST00000356272, ENST00000540628]
14)
Homo sapiens
PHLPP1 - PH domain leucine-rich repeat-containing
protein
phosphatase 1;
Protein
phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr
protein
kinase
family; specifically acts on '
Ser
-473' of AKT2 and AKT3, '
Ser
-660' of PRKCB and '
Ser
-657' of PRKCA. Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors [...]
[a.k.a. 3.1.3.16, R-HSA-9006925, UPI000051AE2E]
15)
Homo sapiens
ADCK1 - AarF domain-containing
protein
kinase
1; Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a
kinase
- independent manner to regulate essential mitochondrial structural
proteins
OPA1 and IMMT. The action of this enzyme is not yet clear (Probable). It is not known if it has
protein
kinase
activity and what type of substrate it would phosphorylate (
Ser
, Thr or Tyr) (Probable).
[a.k.a. UPI0003F47D03, ENSP00000334942, XP_011535289.1]
16)
Homo sapiens
EIF2AK3 - Eukaryotic translation initiation factor 2-alpha
kinase
3; Metabolic-stress sensing
protein
kinase
that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/EIF2S1) on '
Ser
-52' during the unfolded
protein
response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global
protein
synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated [...]
[a.k.a. UPI0010893AAF, XM_017005376, ENST00000652736]
17)
Homo sapiens
TLK1 - Serine/threonine-protein
kinase
tousled-like 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at '
Ser
-10'. Belongs to the
protein
kinase
superfamily. [...]
[a.k.a. ENSP00000397910, AK091975, NM_001136554.1]
18)
Homo sapiens
CPPED1 - Serine/threonine-protein phosphatase CPPED1;
Protein
phosphatase that dephosphorylates AKT family
kinase
specifically at '
Ser
-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.
[a.k.a. 3.1.3.16, ENSG00000103381, HGNC:25632]
19)
Homo sapiens
KSR2 -
Kinase
suppressor of Ras 2; Location-regulated scaffold connecting MEK to RAF. Has very low
protein
kinase
activity and can phosphorylate MAP2K1 at several
Ser
and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8
kinase
activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, [...]
[a.k.a. R-HSA-162582, NP_775869, kinase suppressor of ras 2]
20)
Homo sapiens
CDK16 - Cyclin-dependent
kinase
16;
Protein
kinase
that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at '
Ser
-336' (in vitro).
[a.k.a. ENSG00000102225, CDK16-201, XP_011542230]
2283 matches
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